Table 5.
Modeled results
| 1 in 100 | 1 in 250 | |||
|---|---|---|---|---|
| FPR | DR | FPR | DR | |
| (i) maternal age, PAPP-A & free B-hCG | 4.6 | 77.7 | 9.8 | 87.3 |
| (ii) maternal age, PAPP-A, free B-hCG & ADAM12-S | 4.6 | 77.6 | 9.8 | 87.2 |
| (iii) maternal age, PAPP-A, free B-hCG & NT | 2.5 | 87.0 | 5.1 | 91.9 |
| (iv) maternal age, PAPP-A, free B-hCG, NT & ADAM12-S | 2.5 | 86.9 | 5.2 | 92.0 |
| (v) maternal age, PAPP-A & ADAM12-S | 5.4 | 72.3 | 11.9 | 84.3 |
| (vi) maternal age, PAPP-A, ADAM12-S & NT | 2.8 | 84.1 | 6.0 | 90.0 |
Results for a screening test including maternal age, PAPP-A and ADAM12-S, with and without NT. Modeled detection rates and false-positive rates for fetal trisomy 21 at fixed risk cut-offs of 1 in 100 and 1 in 250.
Increase in FPR and decrease in DR when free B-hCG in (i) is replaced with ADAM12-S to give (v) and when free B-hCG in the combined test (iii) is replaced with ADAM12-S to give (vi).