Table 6.

Detection rate for a fixed false-positive rate: Modelled results

	DR
(i) maternal age, PAPP-A & free B-hCG	78.5
(ii) maternal age, PAPP-A, free B-hCG & ADAM12-S	78.6
(iii) maternal age, PAPP-A, free B-hCG & NT	91.6
(iv) maternal age, PAPP-A, free B-hCG, NT & ADAM12-S	91.7
(v) maternal age, PAPP-A & ADAM12-S	71.0
(vi) maternal age, PAPP-A, ADAM12-S & NT	88.9

Results for first trimester screening test with and without ADAM12-S. Modelled detection rates for fetal trisomy 21 at a fixed false-positive rate of 5%.

Virtually no change in DR when ADAM12-S is added to first trimester biochemistry and when ADAM12-S is added to the combined test.

Substantial reduction in DR when free B-hCG in (i) is replaced with ADAM12-S to give (v) and also reduction in DR when free B-hCG in (iii) is replaced with ADAM12-S to give (vi).