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Tyrosine hydroxylase immunostaining in the striatum. AAV1/2 human A53T alpha-synuclein produced significant reductions in the optical density measurements of tyrosine hydroxylase (TH) compared to empty vector and GFP treated groups 3 weeks following AAV1/2 injection into the substantia nigra. **P < 0.01 c.f. empty vector; ##P < 0.01 c.f. GFP. Scale bar in panel A is 500 μm.
