TABLE 1.

Bioinformatic Analysis of the DR1/DR2 Sites in the Proximal Promoters (2 kb) and Intron1-2 of Drug-Processing Genes That Are Markedly Downregulated in Livers of HNF4a-HNull Mice

Gene name	DR1/DR2 site sequence	DR1/DR2 site location
Ugt2a3	DR1 TGAACTCTGCTCT	Intron1-2
	DR2 TGGCCTAGTCACCC	−346 bp
Ugt2b1	DR1 TGAACCTTGAGCT	−144 bp
Ugt2b36	DR1 TTGTCAAAGGTCA,	−1978 bp
	DR1 AGATAAAAGGTCA	−31 bp
Ugt3a1	DR1 AGGTAATAGGTCA,	Intron1-2
	DR1 TGACCTCTCAGCT,	Intron1-2
	DR2 AGGGCAAAAGGGCA	−34 bp
Ugt3a2	DR1 GAAACTTTGCAC	−855 bp
Sult1a1	DR1 TGAACTCAGACCA	−1717 bp
	DR1 TGTCCTATAACCC	−1024 bp
	DR2 AGGTCAAGGGGGCA	−592 bp
Sult1b1	DR1 TGAACTTTAAGCC	Intron1-2
	DR1 TGTCCTCTGTCCT	Intron1-2
Gstm6	DR1 TGGCCCTTCACCT	−1990 bp
Oat2	DR1 AGCTCACAGGCCA	−1521 bp
	DR1 AGGCCAGGGTTCA	−1240 bp
Oatp1a1	DR1 TGACCTATGATCT	−300 bp
Oatp2b1	DR1 GGATCAAAGGCCA	Intron1-2
	DR1 TGAACTCTGGCCT	Intron1–2
	DR1 TGACCTGTGACCT	Intron1-2
	DR1 TGGCCCCTGACCC	Intron1-2
	DR1 TGACCAGTGAGCT	Intron1-2
	DR1 AGGTGAGAGGGCA	Intron1-2
	DR1 TGACTTCAGACCT	Intron1-2
Npt1	DR1 CCACCTCTGACCT	−893 bp
Sat1	DR1 TGTCCCCTGACCT	−908 bp
Svct1	DR1 AGTGCATAGTCCA	−781 bp
	DR2 TGAACTCGTGACCC	−1824 bp
Mrp6	DR1 TTCCCTGTGACCT	−1093 bp
	DR1 TGGACCTTGCCCT	−104 bp
Mate1	DR1 TGTCCCTTGAACC	−654 bp
CAR	DR1 TGTCCTCTGATCT	−399 bp

Note. The DR1/DR2 sites are predicted by NHRSCAN, a web-based computer program for the prediction of nuclear receptor–binding sites.