Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Sep 10;118(2):530–543. doi: 10.1093/toxsci/kfq273

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. For permissions, please email: journals.permissions@oxfordjournals.org.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 4. — Selenium-induced lethality of a glutaredoxin mutant is not decreased by GSH. Animals were scored for lethality after 12-h exposure to (A) 5mM Na₂SeO₃ or (B) both 5mM Na₂SeO₃ and increasing concentrations of GSH (0–10mM). (A) Comparison of the selenium-induced lethality of the wild-type strain N2 (▪), and the glutaredoxin mutant strain, glrx-21(tm2921) (x). Each data point represents the averages of four to six plates with 10 animals per plate and is presented as the mean percentage of dead animals ± SD. ** p < 0.001, for wild-type and the glrx-21 mutant strain exposed to 5mM Na₂SeO₃ and compared across all other concentrations of Na₂SeO₃ (one-way ANOVA). Note. There is no statistically significant difference in lethality between wild-type and the glrx-21 mutant strain when compared within each concentration of Na₂SeO₃ (Student’s t-test) and across all concentrations except 5mM Na₂SeO₃ (one-way ANOVA). (B) The effects of reduced GSH on the selenium-induced lethality of the wild-type strain N2 (▪), and the glutaredoxin mutant strain, glrx-21(tm2921) (x). Each data point represents the averages of 4–13 plates with 10 animals per plate and is presented as the mean percentage of dead animals ± SD. Note. There is no statistically significant difference in lethality for the glrx-21 mutant strain when compared across all concentrations of GSH (0-10mM) tested (one-way ANOVA). *p < 0.05, compared with all concentrations of GSH (0.01–10mM) exposed wild-type animals and glrx-21 mutant animals, as well as the control (0mM GSH) for the glrx-21 mutant strain; **p < 0.01, compared across all concentrations of GSH (0.01–10mM) and controls for both the wild-type and glrx-21 mutant strains.