Table 2.
Klotho interacts with the daf-2/daf-16 genetic pathway for lifespan modulation. See Table 1 for legend.
| Strains | RNAi | 50th percentilea | Mean lifespan days (+/-SD) | Max lifespan | Codeb | Statisticsc (Log-Rank) | N (Censored)d |
|---|---|---|---|---|---|---|---|
| N2 (wt) | p < 0.0001(H) | ||||||
| p < 0.0001(I) | 266(23) | ||||||
| Control | 19 | 17.48(0.24) | 29 | G | p < 0.0001(J) | ||
| p < 0.0001(G) | |||||||
| p = 0.015(I) | 216(11) | ||||||
| klotho | 16 | 15.76(0.20) | 23 | H | p = 0.001(J) | ||
| daf-16 (mgDf50) | p = 0.996(J) | ||||||
| p < 0.0001(G) | 70(3) | ||||||
| Control | 14 | 14.86(0.29) | 24 | I | p = 0.015(H) | ||
| p = 0.996(I) | |||||||
| p < 0.0001(G) | 135(5) | ||||||
| klotho | 14 | 14.78(0.20) | 25 | J | p = 0.001(H) | ||
| age-1 (mg44) | Control | 24 | 23.59(0.19) | 30 | K | p = 0.077(L) | 223(13) |
| klotho | 24 | 23.87(0.16) | 31 | L | p = 0.077(K) | 358(7) | |
| daf-2 (e1370) | Control | 31 | 30.27(0.19) | 39 | M | p = 0.027(N) | 527(22) |
| klotho | 31 | 30.81(0.16) | 39 | N | p = 0.077(M) | 655(17) | |
| daf-2 (m577) | Control | 27 | 25.77(0.38) | 38 | O | p = 0.002(P) | 286(29) |
| klotho | 26 | 25.19(0.24) | 36 | P | p = 0.002(O) | 547(31) | |