Figure 2.

Comparison of conserved amino acid sequence domains mutated in TLL1 with the corresponding domains in selected metzincins. (a) N-terminal end of the catalytic domain, (b) active centers of selected metalloproteases from astacin family and other selected metzincins. (c) N-terminal end of the CUB3 domain. Symbols: H, amino acid sequence of human polypeptides; M, mutated TLL1; dashes, identical residues as in the polypeptide aligned at the top of the alignment. Colors: yellow, conserved cysteines; pink, histidines coordinating zinc in the active center of the enzyme; red, amino acid sequence in extended catalytic center; green, CUB3 domains in different enzymes; blue, mutations detected in ASD patients.