(a) Island of Newfoundland with locations of families A, B, C and the coastal boat route that services this region. Solid land lines=paved highways, broken land lines=unpaved roads, year=completion of road or highway, TCH=Trans-Canada Highway, Small dotted sea lines=coastal boat service, large dotted sea lines=ferry service to Labrador (top), and Nova Scotia (bottom). (b) Pedigree of family A. Shaded symbols=sensorineural hearing loss. The boxed subpedigree was used for the haplotype analysis.