Table 3. Association of genotypes with the expression of type III HLP.
Type III HLP, N (%) | Normo, N (%) | OR (95% CI) | P-value | |
---|---|---|---|---|
APOC3 3238 G>C | ||||
1/1 | 78 (69.6) | 44 (86.3) | 2.7 (1.1–6.7) | 0.03 |
1/2+2/2 | 34 (30.4) | 7 (13.7) | ||
APOA5 −1131 T>C | ||||
1/1 | 75 (70.8) | 45 (88.2) | 3.1 (1.2–8.0) | 0.02 |
1/2+2/2 | 31 (29.2) | 6 (11.8) | ||
APOA5 c.56 G>C | ||||
1/1 | 84 (79.2) | 46 (90.2) | 2.4 (0.9–6.7) | 0.12 |
1/2+2/2 | 22 (20.8) | 5 (9.8) | ||
LPL c.27 G>A | ||||
1/1 | 100 (88.5) | 51 (98.1) | 6.6 (0.8–52.1) | 0.07 |
1/2+2/2 | 13 (11.5) | 1 (1.9) | ||
Cumulative ¥ | ||||
Non-carrier | 48 (42.5) | 38 (73.1) | 3.7 (1.8–7.5) | <0.0001 |
Carrier | 65 (57.5) | 14 (26.9) |
Type III HLP: type III hyperlipidemic patients; normo: normolipidemic E2/2 subjects; OR: odds ratio; 95% CI: 95% confidence interval; 1/1, homozygous for the common allele; 1/2 heterozygous for the common and rare allele; 2/2, homozygous for the rare allele; cumulative ¥: non-carrier represents non-carrier of the rare allele of either the APOA5 c.56 G>C, SNP3, APOC3 −1131 T>C or LPL c.27 G>A and carrier represents carrier of the rare allele of either the APOA5 c.56 G>C, SNP3, APOC3 −1131 T>C or LPL c.27 G>A.