Table 3. Genotype frequencies of the most common rs449647 (A), rs769446 (B) and rs44405509 (C) according to the APOE genotypes.
| AD (n=169) | Controls (n=99) | |||||
|---|---|---|---|---|---|---|
| N | (%) | N | (%) | OR | 95% CI | |
| (a) | ||||||
| ɛ2+ | ||||||
| A/A | 7 | (4.14) | 12 | (12.12) | 0.215 | 0.082–0.566 |
| A/T | 5 | (2.96) | 4 | (4.04) | 1.422 | 0.374–5.390 |
| T/T | 1 | (0.59) | 1 | (1.01) | 0.800 | 0.062–10.286 |
| ɛ3/ɛ3 | ||||||
| A/A | 58 | (34.32) | 40 | (40.40) | 0.347 | 0.180–0.672 |
| A/T | 15 | (8.88) | 29 | (29.29) | 0.218 | 0.079–0.605 |
| T/T | 3 | (1.78) | 4 | (4.04) | 0.250 | 0.024–3.035 |
| ɛ4+ | ||||||
| A/A | 65 | (38.46) | 6 | (6.06) | 8.633 | 3.536–20.978 |
| A/T | 16 | (9.47) | 4 | (4.04) | 7.333 | 2.204–24.046 |
| T/T | 2 | (1.18) | — | — | — | — |
| (b) | ||||||
| ɛ2+ | ||||||
| T/T | 11 | (7.69) | 14 | (14.14) | 0.459 | 0.201–1.051 |
| T/C | 2 | (6.51) | 2 | (2.02) | 0.364 | 0.057–2.309 |
| C/C | — | — | 1 | (1.01) | — | — |
| ɛ3/ɛ3 | ||||||
| T/T | 59 | (34.91) | 62 | (62.63) | 0.285 | 0.157–0.521 |
| T/C | 14 | (8.28) | 10 | (10.10) | 0.267 | 0.073–0.982 |
| C/C | 3 | (1.78) | 1 | (1.01) | 1.500 | 0.093–25.586 |
| ɛ4+ | ||||||
| T/T | 61 | 36.09) | 7 | (7.07) | 9.739 | 4.243–22.227 |
| T/C | 20 | (11.83) | 2 | (2.02) | 8.000 | 1.696–36.325 |
| C/C | 2 | (1.18) | 1 | (1.01) | 0.667 | 0.039–10.802 |
| (c) | ||||||
| ɛ2+ | ||||||
| G/G | 5 | (2.96) | 3 | (3.03) | 0.647 | 0.157–2.626 |
| G/T | 7 | (4.14) | 13 | (13.13) | 0.224 | 0.084–0.599 |
| T/T | 1 | (0.59) | 1 | (1.01) | 2.000 | 0.192–20.852 |
| ɛ3/ɛ3 | ||||||
| G/G | 36 | (21.30) | 24 | (924.24) | 0.208 | 0.074–0.590 |
| G/T | 35 | (20.71) | 27 | (27.27) | 0.476 | 0.229–0.990 |
| T/T | 5 | (2.96) | 22 | (22.22) | 0.085 | 0.018–0.418 |
| ɛ4+ | ||||||
| G/G | 33 | (19.53) | 2 | (2.02) | 15.654 | 3.851–62.639 |
| G/T | 42 | (24.85) | 6 | (6.06) | 6.500 | 2.540–16.527 |
| T/T | 8 | (4.73) | 2 | (2.02) | 18.400 | 3.217–101.166 |
Abbreviation: AD, Alzheimer's disease.
AD group: ɛ2/ɛ3, 5.92% (n=10); ɛ2/ɛ4, 1.78% (n=3); ɛ3/ɛ3, 44.97% (n=76); ɛ3/ɛ4, 40.83% (n=69); ɛ4/ɛ4, 6.51% (n=11). HWE P=0.931. Control group: ɛ2/ɛ3, 16.16% (n=16); ɛ2/ɛ4, 1.01% (n=1); ɛ3/ɛ3, 73.74% (n=73); ɛ3/ɛ4, 9.09% (n=9). HWE P=0.999.
Significant values are in boldface.