Table 1. Notable azathioprine-related fatalities and serious ADRs reported to the UK Medicines Control Agency from 1 July 1963 until 19 May 2006.
Adverse event | Reported events | Reported fatalities |
---|---|---|
(A) All causes | 1030 | 110 |
(B) Leading serious adverse events associated with fatalities | ||
Pancytopenia | 55 | 3 |
Thrombocytopenia | 32 | 2 |
Leucopenia | 24 | 2 |
Bone marrow depression | 24 | 2 |
Agranulocytosis | 16 | 2 |
Aplastic anemia | 14 | 5 |
Sepsis | 11 | 4 |
Granulocytopenia | 8 | 1 |
Hepatic failure | 5 | 5 |
Febrile neutropenia | 2 | 1 |