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Physical map of the break point region at 8q21.3. The chromosome 8 break point was within a 26.5 kb region (shaded gray) determined by the overlapping ends of the BAC clones RP11-280G8 and RP11-341C1. The break point thus mapped within intron 1b of RUNX1T1 near, and overlapping with some of the break points reported in AML (marked by vertical lines).14
