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The different patterns of hydrogen-bonding features are highlighted. Blue area: hydrogen bond acceptor. Red area: hydrogen bond donor.(a) Substitution of residue p.Asp61Asn. (b) Substitution of residue p.Asp109Glu. (c) Substitution of residue p.Ser111Cys. (d) Substitution of residue p.Thr124Ala. The color reproduction of this figure is available on the html full text version of the manuscript.
