Table 2. Clinical phenotypes associated to premutation FMR1 alleles.

Phenotype	Sample size	Onset	Penetrance (%)
POI	280 females	Adulthood	18.6
FXTAS	85 females	>50 years	16.5
	44 males	>50 years	45.5
Thyroid disease	88 females	Adulthood	15.9
Chronic muscle pain	90 females	Adulthood	24.4