Figure 1.

Hands and feet of (a) patient 1 showing typical central reduction defects of all four extremities, with only one ray present in both feet; (b) patient 2 showing hypoplastic and hyperconvex nails, and on the index finger only the ulnar part of the nail, on the right foot a cutaneous syndactyly of the second and third toes until the proximal interphalangeal joints with an abnormal position of the second toe and a broad hallux; (c) patient 3 showing central reduction defects of all four extremities, and an arteriovenous malformation on the right hand.