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. 2009 Jun 17;17(12):1606–1614. doi: 10.1038/ejhg.2009.99

Figure 1.

Figure 1

Fine mapping of the 70 kb Hereditary Motor and Sensory Neuropathies – Russe (HMSNR) region on 10q (nt 19 536 818–19 606 356 in reference contig NT_008583.16). (a) Known genes: Hexokinase domain containing 1 (HKDC1) , Hexokinase 1 (HK1) and FLJ31406. (b) Alternative exons supported by mRNAs and ESTs. (c) Positions of SNPs and insertion/deletions: grey – previously published;11 black – identified in this study; and boxed – variants not excluded as possible HMSNR mutations by dbSNP and segregation analysis. (d) Recombinant haplotypes used in fine mapping: haplotypes I and II identified in patients K3 and Romanian Gypsy family;11 haplotype III in newly identified patient reduced the critical interval to 26 449 kb.