Table 1. Association between breast cancer and SNPs from the FGFR2 region tested in the population of Western Siberia.
| Number of | Coded allele frequency | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbSNP_rs | Controls | Cases | OR (95% CI) | P | pHWE | CA | OR (95% CI) | P | West Siberia controls | HapMap HCB/JPT | HapMap CEU | |
| rs10510097 | C/C | 247 | 274 | Ref. | — | 0.34 | 0.17 (0.22/0.11) | 0.09 | ||||
| C/T | 223 | 295 | 1.19 [0.95–1.44] | 0.16 | 0.03 | T | 1.09 [0.93–1.2] | 0.29 | ||||
| T/T | 75 | 93 | 1.12 [0.77–1.47] | 0.53 | ||||||||
| rs2981428 | C/C | 249 | 253 | Ref. | — | 0.38 | 0.41 (0.51/0.31) | 0.48 | ||||
| C/A | 309 | 295 | 0.81 [0.49–1.12] | 0.18 | 0.18 | A | 1.05 [0.90–1.20] | 0.54 | ||||
| A/A | 97 | 115 | 0.86 [0.54–1.18] | 0.35 | ||||||||
| rs7895676 | T/T | 188 | 179 | Ref. | – | 0.45 | — | — | ||||
| C/T | 325 | 379 | 1.22 [0.97–1.48] | 0.11 | 0.48 | C | 1.28 [1.12–1.43] | 1.7 × 10−3 | ||||
| C/C | 122 | 190 | 1.64 [1.33–1.94] | 1.6 × 10−3 | ||||||||
| rs2981582 | C/C | 284 | 247 | Ref. | — | 0.33 | 0.25 (0.30/0.20) | 0.42 | ||||
| C/T | 273 | 371 | 1.56 [1.33–1.79] | 1.6 × 10−4 | 0.95 | T | 1.46 [1.30–1.62] | 2 × 10−6 | ||||
| T/T | 71 | 126 | 2.04 [1.70–2.38] | 3.4 × 10−5 | ||||||||
| rs3135718 | A/A | 299 | 251 | Ref. | — | 0.34 | — | — | ||||
| A/G | 285 | 375 | 1.57 [1.34–1.80] | 10−4 | 0.65 | G | 1.43 [1.27–1.58] | 6 × 10−6 | ||||
| G/G | 80 | 128 | 1.91 [1.58–2.23] | 10−4 | ||||||||
| rs3135715 | A/A | 479 | 533 | Ref. | — | 0.15 | 0.24 (0.27/0.22) | 0.23 | ||||
| A/C | 169 | 200 | 1.06 [0.82–1.30] | 0.61 | 0.68 | C | 1.07 [0.86–1.28] | 0.53 | ||||
| C/C | 13 | 17 | 1.18 [0.44–1.91] | 0.67 | ||||||||
| rs4647913 | G/G | 600 | 525 | Ref. | — | 0.04 | — | — | ||||
| G/C | 41 | 36 | 2.63 [0.33-4.94] | 0.41 | 0.06 | C | 0.93 [0.51–1.35] | 0.73 | ||||
| C/C | 3 | 1 | 2.63 [0.36-4.89] | 0.40 | ||||||||
OR, odds ratio; CI, confidence interval; CA: coded allele; HWE: Hardy–Weinberg equilibrium.