Figure 4.
Power of the EURECA test as a function of the interaction coefficient I and the sibling correlation for exposure CE, after accounting for inflated type I error rates due to CE, considering a sample size of 1000 sib pairs. Fixed parameters: disease prevalence, fD=0.1; frequency of exposure, fE=0.2; exposure relative risk, RRE=2; frequency of predisposing genotype(s), fG=0.1; genotypic relative risk, RRG=2. Dotted curves represent computations for recessive models and solid curves for dominant models.