Table 4. SNPs associated with BMI and fat mass in the Sorbian population at P<0.0001.

					Sorbs					British 1958 Birth Cohort				DGI		Cases		Controls		All samples
					BMI		Fat mass					BMI					BMI			Fat mass
CHR	SNP	BP	A1	MAF	P-value	β	P-value	β	GENE	A1	MAF	P-value	β	A1	MAF	P-value	β	P-value	β	P-value	β
7	rs7800783	21 544 705	A	0.156	9.80E−08	−0.072	1.45E−07	−0.176	DNAH11	A	0.030	0.7336	0.190	A	0.035	0.3527	−0.106	0.4343	0.078	0.5181	−0.069
4	SNP_A-2058578	172 165 262	T	0.178	2.15E−07	−0.066	2.52E−06	−0.149	GALNT17	—	—	—	—	T	0.040	0.1274	0.163	0.4368	−0.069	0.5626	−0.057
18	rs4799668	28 670 898	A	0.150	2.25E−07	−0.073	4.70E−07	−0.176	KLHL14	A	0.010	0.5615	0.461	A	0.023	0.4797	0.100	0.1386	0.188	0.7529	0.043
6	rs2253802	30 792 665	T	0.153	5.96E−07	−0.071	8.43E−09	−0.202	MDC1	T	0.040	0.7124	0.164	—	—	—	—	—	—	—	—
15	rs7173766	52 790 731	A	0.010	6.29E−07	0.188	8.88E−05	0.370	C15orf15	—	—	—	—	—	—	—	—	—	—	—	—
11	rs17106280	106 364 880	T	0.146	1.23E−06	−0.072	3.38E−06	−0.170	GUCY1A2	—	—	—	—	—	—	—	—	—	—	—	—
10	rs7092248	104 252 332	G	0.142	1.82E−06	−0.070	1.27E−06	−0.175	ACTR1A	—	—	—	—	—	—	—	—	—	—	—	—
3	rs1533747	133 328 591	G	0.240	2.26E−06	0.044	4.24E−05	0.095	CPNE4			0.8288	−0.042	G	0.299	0.6078	0.023	0.7721	0.011	0.8008	0.011
12	rs2238082	2 356 972	A	0.142	2.37E−06	−0.071	2.16E−06	−0.178	CACNA1C	—	—	—	—	—	—	—	—	—	—	—	—
3	rs9288907	96 629 152	C	0.018	5.36E−06	0.131	6.88E−05	0.287	ENST00000332119	C	0.020	0.3445	0.588	C	0.012	0.7915	0.040	0.4179	−0.128	0.3050	0.147
2	rs16831005	135 371 064	C	0.170	6.38E−06	−0.056	1.64E−06	−0.147	ACMSD	—	—	—	—	—	—	—	—	—	—	—	—
2	rs10183748	48 109 619	T	0.414	1.11E−05	0.035	1.03E−05	0.086	MSH6, FBXO11	T	0.370	0.4231	0.146	T	0.382	0.3655	−0.036	0.9802	0.001	0.9466	−0.003
2	rs10207319	48 109 700	T	0.414	1.11E−05	0.035	1.03E−05	0.086	MSH6, FBXO11	T	0.370	0.4231	0.146	—	—	—	—	—	—	—	—
2	rs6717617	48 104 613	G	0.407	1.47E−05	0.035	9.80E−06	0.088	MSH6, FBXO11	G	0.370	0.4013	0.153	G	0.383	0.3639	−0.037	0.9851	−0.001	0.9539	−0.002
2	rs6729916	48 085 850	T	0.412	1.71E−05	0.034	2.06E−05	0.083	MSH6, FBXO11	T	0.370	0.4613	0.134	T	0.380	0.3321	−0.039	0.7107	0.013	0.9473	0.002
8	rs2083437	62 492 578	C	0.102	2.31E−05	0.058	3.72E−06	0.157	MGC34646	—	—	—	—	—	—	—	—	—	—	—	—
8	rs12164179	26 347 353	A	0.068	4.36E−05	−0.065	8.45E−05	−0.156	BNIP3L	A	0.050	0.6763	−0.170	—	—	—	—	—	—	—	—
13	rs4773396	111 039 718	G	0.495	4.45E−05	−0.032	7.88E−05	−0.077	ENST00000375713	G	0.480	0.0071	−0.478	G	0.445	0.0342	−0.083	0.4680	−0.026	0.3484	−0.035
10	rs12245255	49 985 086	G	0.107	5.02E−05	0.053	6.17E−05	0.130	C10orf72	G	0.120	0.9636	−0.013	—	—	—	—	—	—	—	—
22	rs5759236	41 983 689	A	0.232	6.59E−05	−0.042	2.85E−05	−0.108	SCUBE1	A	0.180	0.8256	0.051	A	0.184	0.8193	0.011	0.9697	0.002	0.6543	0.021
11	rs11231111	62 016 581	T	0.161	7.39E−05	−0.053	5.48E−07	−0.165	AHNAK	T	0.030	0.0692	0.971	—	—	—	—	—	—	—	—
1	rs16843298	195 250 203	A	0.036	9.90E−05	−0.084	2.90E−06	−0.250	ATP6V1G3, PTPRC	A	0.080	0.0019	−1.026	—	—	—	—	—	—	—	—

P-values were calculated under the additive model of inheritance and adjusted for genomic control factor λ (=1.16 for BMI and =1.18 for fat mass), age, gender and first four vectors of MDS for the Sorbian cohort. P-values for the DGI sample are adjusted for genomic control.

Reference allele is the minor allele (A1) for all cohorts. For SNPs not within a gene, the closest gene is given. Only SNPs with both a P-value<0.0001 for BMI and fat mass in the Sorbs are presented (sorted by P-value for association with BMI). Positions (BP) are based on NCBI Build 35 annotation. MAF (minor allele frequency) is given for each cohort.