Figure 5.

Maximum intensity projection (MIP) images of a nude mouse implanted in the right flank with a human colon tumor (LS-174T). Images were reconstructed with maximum a posteriori (MAP) (top row) and ordered subsets expectation maximization (OSEM) (bottom row) algorithms and normalized to reflect decay-corrected relative image intensities at the various times of scan. Uptake values (percentage of injected dose/g of tissue), measured by direct tissue assay, are indicated on the Day 7 MAP image. The tumor weighed 190 mg at the time of sacrifice following the final scan. In part, the apparent enlargement of the tumor images with time reflects tumor growth over the course of the experiment.