Table 3. Associations between haplotypes in TLR2 and TLR4 genes, Plasmodium falciparum susceptibility and mortality.
| P. falciparum | Mortality | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | Ct value (SE) | P-value | HR | 95% CI | |
| TLR4 | ||||||
| H1 | Reference | Reference | Reference | |||
| H2 | 0.89 | 0.52–1.52 | −0.48 (0.29) | 0.10 | 1.17 | 0.91–1.49 |
| H3 | 1.34 | 0.67–2.68 | −0.61 (0.31) | 0.050 | 1.04 | 0.80–1.34 |
| H4 | 0.98 | 0.56–1.71 | −0.64 (0.34) | 0.059 | 0.88 | 0.66–1.16 |
| H5 | 1.15 | 0.51–2.59 | −0.27 (0.43) | 0.54 | 0.92 | 0.66–1.30 |
| H6 | 1.51 | 0.66–3.43 | 0.00 (0.37) | 1.00 | 0.98 | 0.68–1.40 |
| TLR2 | ||||||
| H1 | Reference | Reference | Reference | |||
| H2 | 0.81 | 0.46–1.45 | −0.13 (0.32) | 0.69 | 1.04 | 0.80–1.36 |
| H3 | 0.98 | 0.51–1.87 | 0.22 (0.33) | 0.51 | 1.01 | 0.76–1.33 |
| H4 | 0.67 | 0.35–1.27 | −0.34 (0.38) | 0.37 | 0.95 | 0.70–1.29 |
| H5 | 1.16 | 0.57–2.36 | −0.45 (0.37) | 0.23 | 0.97 | 0.71–1.33 |
| H6 | 0.94 | 0.42–2.13 | 0.82 (0.46) | 0.077 | 0.96 | 0.69–1.34 |
| H7 | 0.90 | 0.40–2.01 | 0.11 (0.42) | 0.79 | 0.96 | 0.68–1.37 |
Abbreviations: HR, hazard ratio; OR, odds ratio; SE, standard error.
Linear, logistic and Cox regression were adjusted for age, sex, compound wealth and tribe. The estimate of cytokine production is expressed as z-scores with SE, which indicate the increase in cytokine production per copy of the haplotype.