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This study compares the rates for the cutinase-mediated deacylation of an immobilized substrate for a surface that presents the substrate alone (A) and a surface that presents the substrate together with an adaptor ligand, which can bind an SH2 domain that is fused to the cutinase enzyme (B). This model system allows direct measurement of the rate enhancement that is realized when the adaptor domain positions the enzyme for an “intramolecular” reaction with its substrate.
