Table 1. Result of the WTCCC GWAS data and the replication analysis.
| WTCCC data | Spanish data | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Ch | SNP | Controls | MS | MAF WTCCC | P-value | OR | Power | Controls | MS | MAF Spain | P-value | OR | CI |
| H6PD | 1 | rs17368528 | 22/330/1113 | 7/182/779 | 0.12 | 0.004 | 0.77 | 0.64 | 17/206/657 | 7/148/569 | 0.13 | 0.04 | 0.801 | (0.648–0.990) |
| CD207 | 2 | rs10489990 | 169/662/635 | 133/479/363 | 0.34 | 0.003 | 1.194 | 0.67 | 167/407/304 | 115/331/278 | 0.42 | 0.04 | 0.865 | (0.751–0.997) |
| TMEM39A | 3 | rs1132200 | 61/432/969 | 27/229/717 | 0.19 | 6E−05 | 0.728 | 0.94 | 19/215/645 | 13/153/556 | 0.14 | 0.09 | ||
| C8orf32 | 8 | rs6470147 | 150/631/685 | 124/460/391 | 0.32 | 0.0009 | 1.225 | 0.77 | 101/395/383 | 109/305/310 | 0.34 | 0.18 | ||
| INPP5A | 10 | rs3818511 | 52/468/946 | 44/374/556 | 0.2 | 0.0003 | 1.283 | 0.84 | 879/0/0 | 723/0/0 | 0 | — | ||
| CHUK | 10 | rs7903344 | 321/742/403 | 265/476/233 | 0.47 | 0.002 | 1.194 | 0.70 | 177/428/274 | 161/366/196 | 0.44 | 0.08 | ||
| SLC35C1 | 11 | rs7130656 | 14/256/1168 | 14/212/738 | 0.1 | 0.005 | 1.130 | 0.2 | 9/198/672 | 10/1439/574 | 0.12 | 0.2 | ||
| STAB2 | 12 | rs1609860 | 7/179/1279 | 5/164/806 | 0.07 | 0.002 | 1.389 | 0.74 | 6/115/755 | 6/109/608 | 0.07 | 0.2 | ||
| GARNL1 | 14 | rs2274068 | 43/369/1054 | 32/304/639 | 0.16 | 0.002 | 1.266 | 0.72 | 26/309/544 | 25/237/462 | 0.21 | 0.58 | ||
| NF1 | 17 | rs11080149 | 18/329/1089 | 30/242/688 | 0.13 | 0.003 | 1.282 | 0.71 | 5/126/748 | 2/100/624 | 0.08 | 0.5 | ||
| SP2 | 17 | rs2229358 | 244/769/452 | 138/476/361 | 0.43 | 0.0012 | 0.835 | 0.72 | 204/427/248 | 167/349/207 | 0.47 | 0.8 | ||
| CEP192 | 18 | rs2282542 | 23/343/1100 | 12/181/782 | 0.13 | 0.004 | 0.768 | 0.68 | 16/212/651 | 10/185/529 | 0.14 | 0.8 | ||
| GIPR | 19 | rs1800437 | 58/514/894 | 31/266/676 | 0.21 | 6E−05 | 0.741 | 0.92 | 28/277/573 | 21/228/476 | 0.19 | 0.8 | ||
| ZNF283 | 19 | rs2195980 | 19/288/1130 | 17/245/706 | 0.11 | 0.002 | 1.316 | 0.73 | 21/220/637 | 14/171/538 | 0.15 | 0.3 | ||
| ZNF45 | 19 | rs407731 | 323/728/374 | 213/482/266 | 0.48 | 0.00191 | 0.962 | 0.1 | 232/430/214 | 178/367/175 | 0.51 | 0.6 | ||
| C19orf48 | 19 | rs4801853 | 144/576/738 | 61/378/532 | 0.3 | 0.004 | 0.824 | 0.70 | 60/316/503 | 47/280/397 | 0.25 | 0.5 | ||
| B3GALT5 | 21 | rs3746887 | 37/415/1013 | 43/304/628 | 0.17 | 0.003 | 1.248 | 0.70 | 39/282/557 | 13/211/499 | 0.21 | 0.003 | 0.761 | (0.635–0.912) |
| DLG3 | 23 | rs2281868 | 148/361/223 | 187/347/170 | 0.45 | 0.0007 | 1.289 | 0.94 | 149/286/174 | 99/214/124 | 0.48 | 0.71 | ||
| DMD | 23 | rs228406 | 77/306/343 | 91/337/276 | 0.32 | 0.004 | 1.259 | 0.88 | 88/265/260 | 42/213/182 | 0.36 | 0.34 | ||
Ch, chromosome; MAF, minor allele frequency.
Significant P-values (P<0.05) are given in bold. Power was calculated for the size of effect detected in the WTCCC GWAS at an α-level of 0.05, assuming a multiplicative allelic effects model, using 732 cases and 974 controls.