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. 2009 Dec 9;18(5):527–532. doi: 10.1038/ejhg.2009.216

Figure 1.

Figure 1

Comparative genomic analysis of the SHOX genomic region using the ECR browser (data according to the March 2006 human reference sequence hg 18, NCBI Build 36.1). Conserved coding elements are shown as blue or yellow bars, conserved non-coding elements are given as red bars. The height of the bars indicates the degree of conservation between the different species, the width of the bars indicates the size of the conserved elements. Four highly conserved elements in the upstream region (CNE-2, CNE-3, CNE-4 and CNE-5) were selected for analysis in the enhancer assays. The CNEs found to act as enhancers in the limb bud are highlighted in light blue.