Table 1b. Summary of the loci for HDL-C in published genome-wide association studies.
| Location | Gene within or near associated interval | Article(reference) |
|---|---|---|
| 1q42 | GALNT2 | Kathiresan et al, 200926; Willer et al, 200827 |
| 2p24 | APOB | Aulchenko et al, 200928 |
| 8p21 | LPL | Aulchenko et al, 200928; Kathiresan et al, 200926; Kooner et al, 200829; Saxena et al, 200730; Wallace et al, 200831; Willer et al, 200827 |
| 9p22 | TTC39B | Kathiresan et al, 200926 |
| 9q31 | ABCA1 | Aulchenko et al, 200928; Kathiresan et al, 200926; Kooner et al, 200829; Wallace et al, 200831; Willer et al, 200827 |
| 11p11.2 | NR1H3, MADD, FOLH1 | Aulchenko et al, 200928; Sabatti et al, 200932 |
| 11q12 | FADS2/3 | Aulchenko et al, 200928 |
| 11q23 | APOA1-APOC3-APOA4-APOA5 | Kathiresan et al, 200926 |
| 12q24 | MVK, MMAB | Kathiresan et al, 200926; Willer et al, 200827 |
| 15q22 | LIPC | Aulchenko et al, 200928; Kathiresan et al, 200926; Kooner et al, 200829; Sabatti et al, 200932; Saxena et al, 200730; Wallace et al, 200831; Willer et al, 200827 |
| 16q13 | CETP | Aulchenko et al, 200928; Kathiresan et al, 200926; Kooner et al, 200829; Sabatti et al, 200932; Saxena et al, 200730; Wallace et al, 200831; Willer et al, 200827 |
| 16q22 | LCAT, CTCF, PRMT8 | Aulchenko et al, 200928; Kathiresan et al, 200926; Sabatti et al, 200932 |
| 17p13 | Sabatti et al, 200932 | |
| 18q21 | LIPG | Aulchenko et al, 200928; Kathiresan et al, 200926; Willer et al, 200827 |
| 19p13 | ANGPTL4 | Kathiresan et al, 200926 |
| 19q13.3 | CLPTM1 | Wallace et al, 200831 |
| 20q13 | HNF4A, PLTP | Kathiresan et al, 200926 |
Abbreviations: GALNT2, GalNAc transferase 2; APOB, apolipoprotein B; LPL, lipoprotein lipase; TTC39B, tetratricopeptide repeat protein 39B; ABCA1, ATP-binding cassette subfamily A member 1; NR1H3, nuclear receptor subfamily1 group H member 3; MADD, map kinase-activating death domain; FOLH1, folate hydrolase 1; FADS2/3, fatty acid desaturase 2, 3; APOA1-APOC3-APOA4-APOA5, apoliprotein A-1, C-3, A-4 and A-5; MVK, mevalonate kinase; MMAB, cobalamin adenosyltransferase; LIPC, hepatic lipase; CETP, cholesteryl ester transfer protein; LCAT, lecithin:cholesterol acyltransferase; CTCF, CCCTC-binding factor; PRMT8, protein arginine methyltransferase 8; LIPG, endothelial lipase; ANGPTL4, angiopoietin-like 4; CLPTM1 cleft lip and palate-associated transmembrane protein 1; HNF4A, hepatocyte nuclear factor 4-alpha; PLTP, phospholipid transfer protein.
All the analyses used population-based cohorts or cohorts with cardiovascular disease-related traits. Most of the studies used combinations of several study samples. The number of subjects in the initial genome-wide scans ranged between 1955 and 21 412 subjects.