Table 2. Characteristics of all the genotyped subjects (quantitative analysis sample) and of the subset of the subjects used for the analysis of low HDL-C trait (qualitative analysis sample).
| Quantitative analysis samplea | Qualitative analysis sampleb | |||
|---|---|---|---|---|
| Men | Women | Men | Women | |
| Number of subjects | 212 | 163 | 137 | 104 |
| Age | 48.6 (13.1) | 49.3 (16.5) | 48.0 (13.9) | 46.3 (17.3) |
| CHD patients | 119 (56 %) | 34 (21 %) | 60 (44%) | 12 (12%) |
| Age at first CHD event | 48.8 (10.1) | 52.9 (9.7) | 49.5 (10.0) | 54.5 (10.2) |
| Low HDL-C patientsc | 55 (26%) | 29 (18%) | 49 (36%) | 24 (23%) |
| Body mass index (kg/m2) | 26.9 (3.9) | 25.5 (4.7) | 26.5 (3.9) | 25.1 (5.1) |
| Total cholesterol (mmol/l) | 5.37 (1.06) | 5.49 (1.15) | 5.44 (1.15) | 5.56 (1.25) |
| HDL cholesterol (mmol/l) | 1.07* (0.29) | 1.39 (0.33) | 1.00* (0.28) | 1.35 (0.35) |
| LDL cholesterol (mmol/l) | 3.33 (0.87) | 3.30 (0.97) | 3.38 (0.95) | 3.36 (1.07) |
| Triglycerides (mmol/l) | 1.78 (1.02) | 1.49 (1.54) | 1.90 (1.14) | 1.55 (1.88) |
| Current smokers | 49 (23 %) | 23 (14 %) | 34 (25%) | 12 (12%) |
| Lipid-lowering drug in use | 34 (16 %) | 6 (4 %) | 21 (15%) | 3 (3%) |
Abbreviations: HDL-C, high-density lipoprotein cholesterol; CHD, coronary heart disease.
Values shown for the subjects genotyped are expressed as means (SD) or numbers of subjects (percentages).
*P<0.05 for the difference between men.
a
Quantitative analysis sample includes characteristics of all the subjects genotyped.
b
Qualitative analysis sample includes only the samples used in the qualitative analysis of the low HDL-C trait.
c
Subjects having their measured HDL-C levels in the lowest 10th percentile for the general population were coded as affected.