Table 2. Performance measures for each model at the 10% threshold.
| Proportion of carriers by model probability | Test parameters at 10% threshold (95% CI) | |||||
|---|---|---|---|---|---|---|
| <10% | ⩾10% | Sensitivity | Specificity | PPV | NPV | |
| Combined | ||||||
| IC MODEL | 0/13 | 10/89 | 1.0 | 0.16 | 0.11 | 1.0 |
| BRCAPRO 4.2 | 0/37 | 10/65 | 1.0 | 0.44 | 0.15 | 1.0 |
| BRCAPRO 5.0 | 2/73 | 8/28 | 0.80 | 0.78 | 0.29 | 0.97 |
| FHAT | 3/77 | 7/25 | 0.70 | 0.73 | 0.28 | 0.96 |
| MYRIAD | 0/0 | 10/102 | 1.0 | 0.0 | 0.10 | — |
| BRCA2 | ||||||
| IC MODEL | 0/15 | 8/87 | 1.0 | 0.18 | 0.09 | 1.0 |
| BRCAPRO 4.2 | 0/41 | 8/61 | 1.0 | 0.46 | 0.13 | 1.0 |
| BRCAPRO 5.0 | 3/76 | 5/26 | 0.63 | 0.78 | 0.19 | 0.96 |
Abbreviations: NPV, negative predictive value; PPV, positive predictive value.