Table 1. Genotype and allele frequencies of IL2, IL2RA and IL2RB polymorphisms in MS patients and healthy controls recruited from Madrid and Andalucía, and overall Mantel–Haenszel analyses of the pooled Spanish cohorts.
| IL2RA | ||||
|---|---|---|---|---|
| MS Madrid | Controls Madrid | MS Andalucía16 | Controls Andalucía16 | |
| rs11938795 | ||||
| TT | 231 (56%) | 293 (54%) | — | — |
| TC | 155 (38%) | 206 (38%) | — | — |
| CC | 26 (6%) | 47 (9%) | — | — |
| T | 617 (75%) | 792 (73%) | — | — |
| C | 207 (25%) | 300 (27%) | — | — |
| Allelic P | 0.25 | |||
| Allelic OR (95% CI) | 0.89 (0.72–1.09) | |||
| rs17388568 | ||||
| GG | 229 (54%) | 289 (54%) | — | — |
| GA | 162 (38%) | 214 (40%) | — | — |
| AA | 35 (8%) | 37 (7%) | — | — |
| G | 620 (73%) | 792 (73%) | — | — |
| A | 232 (27%) | 288 (27%) | — | — |
| Allelic P | 0.78 | |||
| Allelic OR (95% CI) | 1.03 (0.84–1.27) | |||
| rs6822844a | ||||
| GG | 334 (80%) | 405 (74%) | 598 (78%) | 717 (77%) |
| GT | 79 (19%) | 136 (25%) | 160 (21%) | 191 (21%) |
| TT | 6 (1%) | 8 (1%) | 10 (1%) | 21 (2%) |
| G | 747 (89%) | 946 (86%) | 1356 (88%) | 1625 (87%) |
| T | 91 (11%) | 152 (14%) | 180 (12%) | 233 (13%) |
| Allelic P | 0.05 | 0.47 | ||
| Allelic OR (95% CI) | 0.76 (0.57–1.01) | 0.93 (0.75–1.15) | ||
| Allelic PMantel–Haenszel=0.076 | ||||
| Allelic ORMantel–Haenszel (95% CI)=0.86 (0.72–1.01) | ||||
| IL2RA | ||||
| MS Madrid | Controls Madrid | MS Andalucía16 | Controls Andalucía16 | |
| rs11594656b (rs35285258 in Andalucía) | ||||
| TT | 186 (45%) | 251 (46%) | 300 (39%) | 334 (45%) |
| TA | 172 (42%) | 244 (45%) | 366(47%) | 320 (43%) |
| AA | 56 (14%) | 48 (9%) | 105 (14%) | 82 (11%) |
| T | 544 (66%) | 746 (69%) | 966 (63%) | 988 (67%) |
| A | 284 (34%) | 340 (31%) | 576 (37%) | 484 (33%) |
| Allelic P | 0.17 | 0.01 | ||
| Allelic OR (95% CI) | 1.15 (0.94–1.40) | 1.22 (1.04–1.42) | ||
| Allelic PMantel–Haenszel=0.004 | ||||
| Allelic ORMantel–Haenszel (95% CI)=1.19 (1.05–1.33) | ||||
| rs41295061 | ||||
| CC | 381 (91%) | 479 (88%) | 678 (89%) | 650 (87%) |
| CA | 35 (8%) | 66 (12%) | 82 (11%) | 93 (12%) |
| AA | 1 (0%) | 2 (0%) | 1 (0%) | 3 (0%) |
| C | 797 (96%) | 1024 (94%) | 1438 (94%) | 1393 (93%) |
| A | 37 (4%) | 70 (6%) | 84 (6%) | 99 (7%) |
| Allelic P | 0.06 | 0.19 | ||
| Allelic OR (95% CI) | 0.68 (0.44–1.04) | 0.82 (0.60–1.12) | ||
| Allelic PMantel–Haenszel=0.03 | ||||
| Allelic ORMantel–Haenszel (95% CI)=0.77 (0.6–0.97) | ||||
| rs2104286 | ||||
| AA | 303 (72%) | 337 (62%) | 508 (67%) | 483 (64%) |
| AG | 108 (26%) | 183 (34%) | 224 (30%) | 238 (31%) |
| GG | 8 (2%) | 25 (5%) | 21 (3%) | 38 (5%) |
| A | 714 (85%) | 857 (79%) | 1240 (82%) | 1204 (79%) |
| G | 124 (15%) | 233 (21%) | 266 (18%) | 314 (21%) |
| Allelic P | 0.0002 | 0.03 | ||
| Allelic OR (95% CI) | 0.64 (0.50–0.82) | 0.82 (0.68–0.99) | ||
| Allelic PMantel–Haenszel=0.0001 | ||||
| Allelic ORMantel–Haenszel (95% CI)=0.75 (0.65–0.86) | ||||
| IL2RB | ||||
| MS Madrid | Controls Madrid | MS Andalucía | Controls Andalucía | |
| rs743777 | ||||
| AA | 190 (46%) | 242 (45%) | — | — |
| GA | 183 (44%) | 221 (41%) | — | — |
| GG | 40 (10%) | 72 (13%) | — | — |
| A | 563 (68%) | 705 (66%) | — | — |
| G | 263 (32%) | 365 (34%) | — | — |
| Allelic P | 0.30 | |||
| Allelic OR (95% CI) | 0.90 (0.74–1.10) | |||
| rs9622555 | ||||
| GG | 225 (54%) | 267 (49%) | 342 (46%) | 344 (51%) |
| GT | 160 (38%) | 217 (40%) | 335 (45%) | 266 (40%) |
| TT | 34 (8%) | 61 (11%) | 69 (9%) | 62 (9%) |
| G | 610 (73%) | 751 (69%) | 1019 (68%) | 954 (71%) |
| T | 228 (27%) | 339 (31%) | 473 (32%) | 390 (29%) |
| Allelic P | 0.06 | 0.12 | ||
| Allelic OR (95% CI) | 0.83 (0.68–1.02) | 1.14 (0.96–1.34) | ||
ORs referred to the minor allele.
a
Carrier T (Madrid cohort): P=0.03; OR (95% CI)=0.72 (0.52–0.98).
b
Carrier T (Madrid cohort): P=0.02; OR (95% CI)=0.62 (0.4–0.95).