Table 4. Summary of allelic association.

SNPa	Studiesb	Allele 1	Allele 2	Freq Allele 1	Freq SE Allele 1	Min Freq	Max Freq	Weightc	Z scored	P-value
(a) Three replication studies combined
rs3743481	1,4	T	C	0.408	0.024	0.395	0.453	2376	0.75	0.4534
rs9652490	1,3,4	G	A	0.242	0.014	0.231	0.263	3305	3.39	0.0007
rs3144	1,4	C	T	0.312	0.030	0.255	0.328	2374	2.25	0.0242
rs8028808	1,4	A	G	0.168	0.012	0.144	0.174	2382	3.18	0.0015
(b) All four studies combined
rs3743481	1,4	T	C	0.408	0.024	0.395	0.453	2376	0.75	0.4534
rs9652490	1,2,3,4	G	A	0.310	0.034	0.231	0.329	19854	6.74	1.55E-11
rs3144	1,4	C	T	0.312	0.030	0.255	0.328	2374	2.25	0.02421
rs8028808	1,4	A	G	0.168	0.012	0.144	0.174	2382	3.18	0.00148

Only rs9652490 was genotyped in all studies. For each of the remaining SNPs, studies that had the genotype are indicated:

^aIn this study.

^bStefansson et al.¹⁴

^cTan et al.¹⁶

^dVilariño-Güell et al.¹⁵ When alleles were called differently, alleles from this study were used. Weight represents the total number of subjects genotyped. The direction of the Z score represents allelic association with allele 1.