Table 4. Summary of allelic association.
SNPa | Studiesb | Allele 1 | Allele 2 | Freq Allele 1 | Freq SE Allele 1 | Min Freq | Max Freq | Weightc | Z scored | P-value |
---|---|---|---|---|---|---|---|---|---|---|
(a) Three replication studies combined | ||||||||||
rs3743481 | 1,4 | T | C | 0.408 | 0.024 | 0.395 | 0.453 | 2376 | 0.75 | 0.4534 |
rs9652490 | 1,3,4 | G | A | 0.242 | 0.014 | 0.231 | 0.263 | 3305 | 3.39 | 0.0007 |
rs3144 | 1,4 | C | T | 0.312 | 0.030 | 0.255 | 0.328 | 2374 | 2.25 | 0.0242 |
rs8028808 | 1,4 | A | G | 0.168 | 0.012 | 0.144 | 0.174 | 2382 | 3.18 | 0.0015 |
(b) All four studies combined | ||||||||||
rs3743481 | 1,4 | T | C | 0.408 | 0.024 | 0.395 | 0.453 | 2376 | 0.75 | 0.4534 |
rs9652490 | 1,2,3,4 | G | A | 0.310 | 0.034 | 0.231 | 0.329 | 19854 | 6.74 | 1.55E-11 |
rs3144 | 1,4 | C | T | 0.312 | 0.030 | 0.255 | 0.328 | 2374 | 2.25 | 0.02421 |
rs8028808 | 1,4 | A | G | 0.168 | 0.012 | 0.144 | 0.174 | 2382 | 3.18 | 0.00148 |
Only rs9652490 was genotyped in all studies. For each of the remaining SNPs, studies that had the genotype are indicated:
In this study.
Stefansson et al.14
Tan et al.16
Vilariño-Güell et al.15 When alleles were called differently, alleles from this study were used. Weight represents the total number of subjects genotyped. The direction of the Z score represents allelic association with allele 1.