Table 2. Sensitivity, specificity and misclassification rates for five SNP logistic regression models predicting HLA allele carrier status.

HLA allele	Mean test set sensitivity (95% CI)	Mean test set specificity (95% CI)	Number of CEPH carriers (%)	Mean CEPH sensitivity (95% CI)	Mean CEPH specificity (95% CI)	Mean CEPH misclassification (95% CI)
HLA-A*01	0.953 (0.901, 1.00)	0.869 (0.745, 0.989)	23 (35.4)	0.935 (0.925, 0.944)	0.999 (0.996, 1.00)	0.0453 (0.0385, 0.0521)
HLA-A*02	0.878 (0.770, 0.987)	0.762 (0.695, 0.829)	40 (61.5)	0.937 (0.765, 1.00)	0.823 (0.776, 0.882)	0.147 (0.124, 0.170)
HLA-A*03	0.974 (0.953, 0.996)	0.949 (0.867, 1.00)	18 (27.7)	0.936 (0.875, 0.997)	0.982 (0.924, 1.00)	0.0540 (0.00501, 0.103)
HLA-A*29	0.977 (0.945, 1.00)	0.826 (0.677, 0.976)	3 (4.6)	0.997 (0.978, 1.00)	0.943 (0.678, 1.00)	0.00748 (0.000201, 0.0351)
HLA-B*07	0.907 (0.863, 0.952)	0.793 (0.656, 0.930)	19 (29.2)	0.863 (0.923, 0.903)	0.834 (0.730, 0.937)	0.147 (0.124, 0.168)
HLA-B*08	0.952 (0.921, 0.983)	0.859 (0.702, 1.00)	17 (26.2)	0.882 (0.850, 0.913)	0.914 (0.785, 1.00)	0.114 (0.0862, 0.142)
HLA-B*44a	0.818 (0.726, 0.910)	0.686 (0.508, 0.863)	23 (35.4)	0.722 (0.590, 0.853)	0.938 (0.758, 1.00)	0.265 (0.135, 0.394)
HLA-B*57	0.954 (0.926, 0.982)	0.708 (0.496, 0.920)	0 (0)	—	—	—
HLA-C*0701	0.828 (0.784, 0.873)	0.818 (0.690, 0.946)	22 (33.8)	0.828 (0.812, 0.843)	0.765 (0.687, 0.844)	0.191 (0.161, 0.220)
HLA-C*0702	0.889 (0.840, 0.938)	0.753 (0.608, 0.898)	3 (4.6)	0.972 (0.949, 0.995)	0.106 (0.0347, 0.177)	0.225 (0.178, 0.272)
HLA-C*05	0.964 (0.928, 1.00)	0.773 (0.638, 0.908)	4 (6.2)	0.924 (0.922, 0.927)	0.0 (0.0, 0.0)	0.247 (0.221, 0.273)
HLA-C*06	0.997 (0.992, 1.00)	0.946 (0.829, 1.00)	0 (0)	—	—	—
HLA-C*16	0.977 (0.955, 0.999)	0.870 (0.375, 1.00)	3 (4.6)	0.972 (0.960, 0.985)	0.828 (0.275, 1.00)	0.0405 (0.00680, 0.0742)

Abbreviation: CI, confidence interval.

^aThis model contains four SNPs.