. 2010 Mar 31;18(8):924–932. doi: 10.1038/ejhg.2010.32

Table 3. Association tests for Hardy–Weinberg equilibrium (HWE), minor allele frequencies and F_ST for 20 most strongly associated HLA alleles, blocks and haplotypes with north–south status.

Marker	Location	Gene symbol	Function	Combined MAF	Combined HWE −log₁₀ P-value	North–south single SNP association –log₁₀ P-value¹	North–south single block association −log₁₀ P-value (r²≥0.5)	North–south F_ST	North MAF	North HWE −log₁₀ P-value	South MAF	South HWE −log₁₀ P-value
rs411136	33516520	SYNGAP1	Ser556Ser	0.15	4.00	32.42 (28.57)	—	0.29	0.33	0.37	0.034	0.00
rs1265160	31246350	POU5F1	Phe3Phe	0.070	0.66	11.15 (11.55)	—	0.099	0.15	1.44	0.023	0.00
rs3096702	32300309	NOTCH4	5' region	0.29	0.08	9.20 (8.29)	—	0.087	0.42	0.39	0.22	0.02
rs2256328	31489616	MICA	Intron	0.24	0.33	8.87 (9.10)	—	-0.0021	0.12	0.93	0.31	0.24
rs2256594	32294850	NOTCH4	Intron	0.13	0.00	8.46 (8.11)	—	0.078	0.21	0.36	0.073	0.10
rs2535318	31159367	—	—	0.49	0.06	7.48 (6.66)	—	0.070	0.37	0.00	0.44	0.19
rs659445	31972283	EHMT2	Intron	0.28	0.57	7.07 (5.91)	—	0.066	0.39	0.16	0.22	0.03
Block 20	33438959–33454164	—	1–1 haplotype	0.40	0.23	—	6.36 (3.96)	0.030	0.42	0.35	0.60	0.09
Block 10	31159367–31186474	C6orf15	2–1 haplotype	0.42	0.51	—	5.65 (4.83)	0.037	0.51	0.71	0.34	0.19
rs389883	32055439	STK19	Intron	0.23	0.10	5.49 (4.87)	—	0.050	0.31	0.07	0.17	0.33
rs2855453	33242370	COL11A2	Intron	0.31	0.97	5.44 (4.51)	—	0.047	0.40	0.00	0.25	0.88
Block 8	30832409–30847883	—	1–1 haplotype	0.16	0.15	—	5.4 (4.15)	0.031	0.72	0.00	0.85	0.10
HLA-B07/ C0702
Haplotype	—	HLA-B/C	—	—	—	—	5.32 (5.32)	0.050	0.16	—	0.060	—
rs1800684	32259972	AGER, PBX2	Ala3Ala, 3' region	0.087	0.16	5.29 (5.07)	—	0.042	0.14	0.20	0.053	0.03
rs1810472	33191099	—	—	0.32	0.23	5.14 (4.74)	—	0.048	0.23	0.00	0.38	0.65
rs4713505	32212979	—	—	0.31	1.58	5.13 (4.01)	—	0.045	0.22	0.59	0.37	0.70
HLA-B^08/ C^0701 Haplotype	—	HLA-B/C	—	—	—	—	4.47 (4.82)	0.042	0.13	—	0.049	—
rs8512	30819336	IER3	3' UTR	0.19	4.39	2.34 (4.74)	—	0.017	0.14	0.00	0.22	6.64
rs211452	33438959	—	—	0.40	0.23	4.69 (4.11)	—	0.039	0.31	0.35	0.46	0.090
Block 17	32331236–32345991	—	2–1 haplotype	0.32	0.13	—	4.31 (4.64)	0.024	0.21	0.00	0.11	0.00

SNPs shown are associated with north–south status after Bonferroni correction for all allelic and genotypic tests.

P-values for association tests are shown as allele-based first, genotype-based in parentheses.

Table 3. Association tests for Hardy–Weinberg equilibrium (HWE), minor allele frequencies and FST for 20 most strongly associated HLA alleles, blocks and haplotypes with north–south status.

Table 3. Association tests for Hardy–Weinberg equilibrium (HWE), minor allele frequencies and F_ST for 20 most strongly associated HLA alleles, blocks and haplotypes with north–south status.