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Slipped mispairing and the role of trimming enzymes. If replication of tandem repeats arrests in the second repeat or in regions outside the repeat, after slipped misalignment at the repeats, an unpaired 3′ tail would be produced. ExoVII may promote deletion in the absence of ExoI by digestion of this unpaired flap. Removal of this tail produces a base-paired 3′ end that can prime DNA synthesis.
