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Selective inhibition of AP-1 transcription by PNRI-299. (a) Inhibition in A549 cells transiently transfected with an AP-1 luc reporter gene construct stimulated with phorbol 12-myristate 13-acetate (PMA). (b) Inhibition in A549 cells transiently transfected with an NF-κB luc reporter gene construct stimulated with PMA. (c) Inhibition of TRX activity by assessing reduction of Ellman's reagent by TRX reductase-activated TRX (22).
