Table 2. Two-point parametric linkage analysis in the whole HC6 family.

		LOD score at
Marker	Position (bp)	θ =0.00	θ =0.05	θ =0.10	θ =0.15	θ =0.20	θ =0.25	θ =0.30
D16S3043	64 049 873–64 049 998	−4.82	−1.16	−0.68	−0.41	−0.25	−0.14	−0.08
D16S3031	64 338 902–64 339 161	−1.29	1.32	1.46	1.44	1.34	1.18	0.98
rs725131	65 143 211	3.36	3.17	2.92	2.62	2.28	1.91	1.51
D16S3107	66 215 439–66 215 732	3.77	3.46	3.14	2.81	2.45	2.07	1.67
D16S496	67 506 219–67 506 438	1.23	1.15	1.02	0.84	0.64	0.42	0.21
D16S3067	67 666 169–67 666 312	3.91	3.59	3.26	2.91	2.54	2.14	1.73
rs904809	68 508 792	0.77	0.80	0.79	0.75	0.68	0.60	0.50
rs722579	69 085 725	0.92	0.96	0.94	0.89	0.82	0.73	0.62
rs1004330	69 590 464	1.17	1.06	0.94	0.82	0.69	0.56	0.42
rs951939	70 367 035	1.16	1.18	1.15	1.08	0.99	0.88	0.74
rs952160	70 523 226	1.83	1.80	1.71	1.59	1.44	1.27	1.07
D16S3106	70 745 261–70 745 460	1.62	1.51	1.34	1.13	0.88	0.62	0.36
rs811047	70 818 194	1.25	1.17	1.03	0.86	0.66	0.45	0.25
rs1383361	72 231 717	1.41	1.28	1.14	1.00	0.85	0.70	0.53
D16S512	72 625 213–72 625 415	0.62	0.65	0.64	0.59	0.52	0.43	0.33
D16S3018	72 730 203–72 730 462	1.72	1.85	1.85	1.76	1.62	1.42	1.17
rs725710	73 431 014	1.27	1.15	1.02	0.89	0.75	0.61	0.46
D16S538	74 438 373–74 438 918	1.76	1.58	1.39	1.20	0.99	0.79	0.59
D16S3083	75 042 911–75 043 109	2.41	2.20	1.99	1.76	1.52	1.27	1.01
D16S515	75 074 576–75 074 715	1.36	1.47	1.48	1.42	1.33	1.19	1.02
D16S3097	75 946 568–75 946 765	1.48	1.32	1.17	1.01	0.86	0.72	0.57
D16S3138	76 161 268–76 161 492	1.79	1.76	1.67	1.55	1.41	1.24	1.04
rs254770	76 435 072	−4.48	−0.67	−0.44	−0.31	−0.22	−0.16	−0.11
D16S518	76 695 528–76 695 807	−11.64	−1.53	−0.64	−0.18	0.08	0.22	0.27

The parameters used for this analysis were dominant inheritance, reduced penetrance of the disease trait (0.9), and frequency of the disease-causing allele at 0.004% (SuperLink v1.5).