Table 2.

Reported weight and metabolic changes with pediatric olanzapine treatment

Parameter study	Treatment duration	Olanzapine N	Observed changes		P value between drugs
			Olanzapine	Other agents
Weight gain
Lilly placebo database110	3–6 wk	179	3.9 kg	Placebo 0.2 kg	P < 0.001
Lilly total exposure database110	up to 32 wk	450	7.4 kg
Kumra et al91	8 wk	8	3.4 kg
Frazier et al62	8 wk	23	5 kg
Ratzoni et al111	12 wk	21	7.2 kg	Risperidone 3.9 kg Haloperidol 1.1 kg	P = 0.02
Ross et al97	6 wk	19	3.8 kg 12.8 kg/12 mo
Findling et al96	8 wk	16	6.5 kg
Mozes et al93	12 wk	9	6.1 kg
Sikich et al30	8 wk	16	7.2 kg	Risperidone 4.9 kg Haloperidol 3.6 kg	P = 0.0009
Shaw et al94	8 wk	12	3.6 kg	Clozapine 3.8 kg
Mozes et al112	12 wk	12	5.8 kg	Risperidone 4.5 kg
Fleischhaker et al113	6 wk	15	4.6 kg	Risperidone 2.8 kg Clozapine 2.5 kg	P = 0.03
Quintana et al98	10 wk	16	6.2 kg
Sikich et al31	8 wk	35	6.1 kg	Risperidone 3.6 kg Molindone 0.3 kg	P = 0.0001
Kumra et al95	12 wk	21	BMI 0.7 kg/m2	Clozapine 0.7 kg/m2
Castro-fornieles et al101	24 wk	16	11.7 kg	Risperidone 6.1 kg Quetiapine 6.0 kg	P = 0.02
Dittmann et al99	6 wk 24 wk	96 32	5.1 kg 11.7 kg
Fleischhaker et al114	45 wk	8	16.2 kg	Risperidone 7.2 kg Clozapine 9.5 kg
Correll et al115	12 wk	45	8.5 kg	Risperidone 5.3 kg Quetiapine 6.1 kg Aripiprazole 4.4 kg
Fasting glucose
Lilly placebo database110	3–6 wk	179	3.6 mg/dL	Placebo −3.6 mg/dL	P < 0.001
Lilly total exposure database110	up to 32 wk	450	1.8 mg/dL
Sikich et al30	8 wk	16	10.0 mg/dL	Risperidone −7.9 mg/dL Haloperidol −0.3 mg/dL
Sikich et al31	8 wk	35	0.6 mg/dL	Risperidone 1.2 mg/dL Molindone 0.9 mg/dL
Kumra et al95	12 wk	21	3.6 mg/dL	Clozapine 4.5 mg/dL
Correll et al115	12 wk	45	3.1 mg/dL	Risperidone 1.1 mg/dL Quetiapine 2.6 mg/dL Aripiprazole 0.5 mg/dL
HOMA-IR
Sikich et al31	8 wk	35	1.2	Risperidone 0 Molindone 0.5
Correll et al115	12 wk	45	0.62	Risperidone 0.2 Quetiapine 0.35 Aripiprazole 0.55
Total cholesterol
Lilly placebo database110	3–6 wk	179	11.7 mg/dL	Placebo 0.0	P = 0.002
Lilly total exposure database110	up to 32 wk	450	7.8 mg/dL
Sikich et al31	8 wk	35	19.9 mg/dL	Risperidone10.2 mg/dL Molindone 0 mg/dL	P < 0.002
Kumra et al95	12 wk	21	17.2 mg/dL
Correll et al115	12 wk	45	15.6 mg/dL	Risperidone 3.5 mg/dL Quetiapine 9.1 mg/dL Aripiprazole 2.8 mg/dL
LDL cholesterol
Lilly placebo database110	3–6 wk	179	7.8 mg/dL	Placebo 0 mg/dL	P = 0.002
Lilly total exposure database110	up to 32 wk	450	7.8 mg/dL
Sikich et al30	8 wk	16	7.6 mg/dL	Risperidone 2.9 mg/dL Haloperidol 0.1 mg/dL
Sikich et al31	8 wk	35	14.7 mg/dL	Risperidone −9.6 mg/dL Molindone 0.5 mg/dL	P = 0.003
Correll et al115	12 wk	45	11.5 mg/dL	Risperidone 0.2 mg/dL Quetiapine 3.9 mg/dL Aripiprazole 7.4 mg/dL
Triglycerides
Lilly placebo database110	3–6 wk	179	26.7 mg/dL	Placebo −8.9 mg/dL	P = 0.007
Lilly total exposure database110	up to 32 wk	450	26.7 mg/dL
Sikich et al30	8 wk	16	26 mg/dL	Risperidone −2 mg/dL Haloperidol 22 mg/dL
Sikich et al31	8 wk	35	21.6 mg/dL	Risperidone 7.1 mg/dL Molindone −5.8 mg/dL
Kumra et al95	12 wk	21	11.4 mg/dL	Clozapine 16.8 mg/dL
Correll et al115	12 wk	45	24.3 mg/dL	Risperidone 9.7 mg/dL Quetiapine 37.0 mg/dL Aripiprazole −2.4 mg/dL