Table 3.
Median (10th, 90th centiles) for selected cytokines and their receptors on 3 different days by gestational age category in the entire sample and in strata defined by the presence or absence of histologic inflammation. Protein concentrations are pg/mg total protein
| Protein | Median (10th , 90th centile) | |||
|---|---|---|---|---|
| GA | Day 1 | Day 7 | Day 14 | |
| Entire sample | ||||
| IL-1β × 103 |
23-24 | 72 (0, 463) | 64 (0, 231) | 75 (0, 228) |
| 25-26 | 48 (0, 234) | 45 (0, 148) | 55 (0, 180) | |
| 27 | 37 (0, 218) | 30 (0, 166) | 48 (0, 175) | |
| IL-6 × 103 |
23-24 | 28 (6, 698) | 12 (5, 44) | 14 (5, 40) |
| 25-26 | 23 (5, 421) | 11 (4, 35) | 11 (4, 46) | |
| 27 | 16 (5, 153) | 7 (2, 28) | 7 (3, 24) | |
| IL-6R | 23-24 | 69 (28, 154) | 118 (54, 216) | 133 (58, 259) |
| 25-26 | 70 (32, 143) | 114 (63, 200) | 124 (63, 211) | |
| 27 | 64 (29, 114) | 105 (56, 179) | 116 (61, 197) | |
| TNF-α × 103 |
23-24 | 69 (11, 240) | 81 (25, 189) | 102 (40, 240) |
| 25-26 | 54 (17, 180) | 61 (22, 142) | 74 (29, 188) | |
| 27 | 42 (11, 126) | 44 (16, 119) | 57 (18, 141) | |
| TNF-R1 | 23-24 | 15 (6, 40) | 21 (10, 47) | 26 (12, 59) |
| 25-26 | 12 (5, 34) | 16 (8, 34) | 19 (8, 40) | |
| 27 | 10 (4, 24) | 12 (6, 25) | 14 (7, 30) | |
| TNF-R2 | 23-24 | 19 (7, 46) | 27 (13, 60) | 37 (17, 81) |
| 25-26 | 17 (7, 42) | 25 (12, 50) | 30 (14, 63) | |
| 27 | 13 (6, 34) | 19 (10, 39) | 23 (12, 50) | |
| Inflamed placenta | ||||
| IL-1β × 103 |
23-24 | 104 (14, 584) | 80 (0, 300) | 82 (22, 242) |
| 25-26 | 85 (6, 368) | 50 (0, 160) | 53 (0, 175) | |
| 27 | 74 (0, 375) | 57 (0, 266) | 44 (0, 134) | |
| IL-6 × 103 |
23-24 | 39 (6, 3446) | 14 (5, 43) | 15 (5, 54) |
| 25-26 | 48 (7, 1270) | 11 (4, 31) | 10 (4, 38) | |
| 27 | 22 (5, 652) | 8 (3, 35) | 6 (1, 20) | |
| IL-6R | 23-24 | 68 (27,148) | 133 (61. 244) | 137 (67, 258) |
| 25-26 | 81 (32, 163) | 128 (73, 211) | 122 (73, 204) | |
| 27 | 74 (30, 149) | 117 (63, 206) | 111 (55, 170) | |
| TNF-α × 103 |
23-24 | 85 (25, 318) | 87 (14, 184) | 118 (39, 290) |
| 25-26 | 73 (24, 237) | 68 (21, 150) | 63 (27, 166) | |
| 27 | 57 (10, 171) | 49 (15, 190) | 48 (7, 112) | |
| TNF-R1 | 23-24 | 18 (8, 42) | 26 (11, 54) | 31 (13, 70) |
| 25-26 | 18 (8, 46) | 19 (8, 38) | 18 (9, 38) | |
| 27 | 14 (6, 37) | 12 (7, 31) | 12 (6, 27) | |
| TNF-R2 | 23-24 | 22 (10, 53) | 32 (13, 65) | 40 (18, 85) |
| 25-26 | 23 (11, 54) | 27 (13, 62) | 32 (15, 64) | |
| 27 | 21 (8, 47) | 18 (10, 38) | 19 (11, 36) | |
| Non-inflamed placenta | ||||
| IL-1β × 103 |
23-24 | 46 (0, 276) | 52 (0, 172) | 69 (0, 216) |
| 25-26 | 27 (0, 129) | 41 (0, 145) | 56 (0, 185) | |
| 27 | 27 (0, 130) | 24 (0, 112) | 49 (0, 182) | |
| IL-6 × 103 |
23-24 | 26 (6, 310) | 10 (4, 59) | 13 (5, 29) |
| 25-26 | 19 (4, 114) | 11 (4, 38) | 11 (4, 48) | |
| 27 | 15 (4, 105) | 7 (2, 26) | 8 (3, 27) | |
| IL-6R | 23-24 | 71 (29, 156) | 103 (51, 189) | 130 (54, 259) |
| 25-26 | 63 (33, 116) | 102 (57, 184) | 127 (61, 214) | |
| 27 | 60 (28, 104) | 100 (54, 165) | 119 (63, 199) | |
| TNF-α × 103 |
23-24 | 53 (9, 175) | 76 (30, 195) | 83 (41, 196) |
| 25-26 | 41 (11, 115) | 57 (22, 129) | 81 (31, 215) | |
| 27 | 36 (11, 105) | 43 (16, 99) | 58 (21, 160) | |
| TNF-R1 | 23-24 | 14 (4, 36) | 17 (9, 40) | 25 (12, 52) |
| 25-26 | 9 (5, 24) | 14 (8, 31) | 20 (8, 42) | |
| 27 | 8 (4, 21) | 12 (6, 23) | 16 (7, 31) | |
| TNF-R2 | 23-24 | 17 (6, 36) | 22 (12, 52) | 34 (16, 74) |
| 25-26 | 12 (7, 29) | 23 (11, 48) | 28 (14, 61) | |
| 27 | 11 (6, 25) | 19 (11, 39) | 26 (12, 52) | |