Table 2.
Functional effects of dopamine receptor agonists.
| Structure | Effects of dopamine or non-specific D1LR/D2LR agonists | D1LR agonist effects | D2LR agonist effects |
|---|---|---|---|
| GPe | Increases firing rate (Napier et al., 1991) | Increases glutamate release (Hernandez et al., 2007) | Increases firing rate (Hadipour Niktarash et al., 2008; unpublished observations) |
| Decreases GABA transmission (Bergstrom and Walters, 1984) | Increases GABA release (Floran et al., 1990) | Increased c-fos (Billings and Marshall, 2003) Decreases GABA release (Floran et al., 1997) | |
| Increases GABA release (Floran et al., 1990) | Decreases GABA-A currents (Cooper and Stanford, 2001; Shin et al., 2003) | ||
| Decreases glutamate release (Hernandez et al., 2007) | |||
| STN | Increases firing rate (Ni et al., 2001; Zhu et al., 2002; Cragg et al., 2004) | Increases firing rate (Mintz et al., 1986; Ni et al., 2001; Rommelfanger et al., 2010) | Increases firing rate (Rommelfanger et al., 2010) |
| Decreases GABA transmission (Shen and Johnson, 2000; Cragg et al., 2004; Baufreton and Bevan, 2008)
Increases oscillations (Shen and Johnson, 2000; Cragg et al., 2004) Decreases bursting (Baufreton and Bevan, 2008) |
Increases bursting (D5) (Baufreton et al., 2003)
Decreases firing rate (Hassani and Feger, 1999) |
Decreases GABA release (Floran et al., 2004)
Decreases GABA-A currents (Shen and Johnson, 2000; Cragg et al., 2004; Baufreton and Bevan, 2008) Decreases firing rate (Hassani and Feger, 1999) |
|
| Decreases glutamate transmission (Shen and Johnson, 2000) | |||
| Decreases firing rate (Campbell et al., 1985; Hassani and Feger, 1999) | |||
| GPi | Increases GABA release (Floran et al., 1990) | Decreases firing rate (Kliem et al., 2007a)
Increases GABA release (Ferre et al., 1996; Kliem et al., 2007a) Increases oscillations (Kliem et al., 2007a) Increases bursting (Kliem et al., 2007a) |
Decreases firing rate (Hadipour Niktarash et al., 2008; unpublished observations) |
| SNr | Decreases multiunit activity (Timmerman and Abercrombie, 1996) | Decreases firing rate (Timmerman and Abercrombie, 1996; Kliem et al., 2007a) | Decreases firing rate (unpublished observations) |
| Increases GABA release (Floran et al., 1990) | Increases GABA release (Timmerman and Westerink, 1995; Rosales et al., 1997; Matuszewich and Yamamoto, 1999; Trevitt et al., 2002; Acosta-Garcia et al., 2009) | Inhibits GABA transmission (Martin and Waszczak, 1996)
Decreases GABA release (Matuszewich and Yamamoto, 1999), (D4) (Acosta-Garcia et al., 2009) |
|
| Increases oscillations (Kliem et al., 2007a)
Increases bursting (Kliem et al., 2007a) Increased firing rate (Waszczak, 1990; Martin and Waszczak, 1994) Decreases GABA transmission (Miyazaki and Lacey, 1998; Radnikow and Misgeld, 1998) Increases glutamate release (Rosales et al., 1997) Increases glutamate transmission (Ibanez-Sandoval et al., 2006) |
Decrease GABA transmission (Waszczak, 1990) |