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Pharmacokinetic Parameter Estimates Following a Single Oral Dose of 4 or 100 mg/kg of Pazopanib
| Nominal Dose (mg/kg) | Cmax (μg/mL) | Tmax (min) | AUC (0-t) (μg.hr/mL) | Estimated AUC (μg.hr/mL) (BID dose) |
|---|---|---|---|---|
| 4 | 13.5 | 123 | 129.6 | 259 (8 mg/kg/day) |
| 100 | 91.4 | 122 | 753.0 | 1,506 (200 mg/kg/day) |
AUC(0-t) refers to the area from time 0 to the last quantifiable concentration
