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Donor small intestine, fully allogeneic bidirectional model: A. control animal (group IA) at 8 days showing cryptitis and inflammation of the lamina propria (H&E; × 100); B. FK-506–treated animal (group IIA) at 22 days showing normal villi and crypts (H&E; ×63); and C. CsA-treated animals (group VII) at 26 days demonstrating severe cryptitis and inflammation in the lamina propria (H&E; ×100).
