Table 3.
Host survival and clinical rejection in a unidirectional, semiallogeneic model ([ACl×LEW] F1→LEW) of small intestine transplantation in the rata
| Group | n | Treatment | Survival times (days) | Mean survival ±SD (days) |
P valueb | Acute rejection |
Chronic rejection |
|---|---|---|---|---|---|---|---|
| IB | 8 | — | 12, 11, 10, 9, 9, 8, 7, 6 | 9.0±2.0 | — | 8/8 | 0/8 |
| IIB | 10 | FK long course | >206, >205, >139, 117, 32, 23, 12, 12, 8, 8 |
83.0±82.6 | 0.0022 | 3/10c | 1/10 |
a
Genetically restricted to graft rejection; GVHD is not possible in this model.
b
Generalized savage (Mantel-Cox) value comparing survival times to that of untreated controls.
c
Chi-square, P value <0.05.