Table 4.

Host survival and clinical GVHD in a unidirectional, semiallogeneic model (LEW→[ACI×LEW] F₁) of small intestine transplantation in the rat^a

Group	n	Treatmentb	Survival times (days)	Mean survival ±SD (days)	P valuec	GVHD
IC	14	—	25, 24, 21, 17, 17, 16, 12, 11, 11, 10, 9, 8, 7, 7	13.9±6.1	—	6/14 d
IIC	8	FK long course	>214, >214, >213, >213, >212, >206, >202, 7	188.0±72.1	0.0002	1/8e,f
VIII	6	CsA 20 inter- mediate course	>104, 53, 50, 8, 7, 7	38.3±38.6	0.1035	2/6

^aGenetically restricted to GVHD; graft rejection is not possible in this model.

^bRefer to Table 1.

^cGeneralized savage (Mantel-Cox) value comparing survival times to that of untreated controls.

^dFour other animals demonstrated findings suggestive of GVHD.

^eChi-square, P value <0.05.

^fLone animal that developed GVHD is alive with resolution of the disease.