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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Neuron. 2010 Nov 4;68(3):500–511. doi: 10.1016/j.neuron.2010.09.026

Fig. 6. Electrical stimulation of dopaminergic fibers affects AIS Ca2+.

Fig. 6

(A) AP train-evoked (top) Ca2+ transients (bottom) in the AIS, imaged with Fluo-4FF. Ca2+ transients were imaged before (black) and after (grey) dopamine release evoked with local electrical stimulation.

(B) Same as (A), but with 300 nM cocaine present throughout experiment.

(C) Same as (A), but with 300 nM cocaine and 200 nM sulpiride present throughout experiment.

(D) Summary of endogenous dopaminergic fiber stimulation experiments. Values normalized to baseline ΔG/R amplitudes. Dots are single cells. Grey bar represents 2x standard deviation of the cocaine+sulpiride condition, centered on its mean. Any decrements in Ca2+ transients below this bar were considered successes.