Figure 5.

DAGLα and MGL expression in CB₁R^−/− telencephalon. A, CB₁Rs decorate corticofugal axons coursing in the cortical IZ and descending in fascicles through striatal patches. A₁, Axonal CB₁R immunoreactivity is entirely absent in CB₁R^−/− mice. B, B₁, DAGLα expression is essentially unchanged in CB₁R^−/− brains in both the cerebral cortex and the hippocampal fimbria (B′, arrow). At cellular resolution, DAGLα localizes to radial glia fibers and enlarged axon clusters in the IZ of CB₁R^−/− mice (B₁′, arrows). C, C₁, Similarly, CB₁R deletion does not affect MGL expression in (C₁) and targeting to (C₁′, arrows) axons in the cerebral cortex. Open rectangles identify the location of insets in A′–C₁′. Scale bars, 50 μm.