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. Author manuscript; available in PMC: 2010 Nov 18.
Published in final edited form as: Mol Ther. 2005 Dec 1;13(3):517–527. doi: 10.1016/j.ymthe.2005.10.008

FIG. 6.

FIG. 6

AAV8 GFP gene transfer induces partial loss of substantia nigra dopamine neurons. (A) Tyrosine hydroxylase immunofluorescence of uninjected substantia nigra, contralateral to B. (B) Tyrosine hydroxylase immunofluorescence 4 weeks after injection of 1 × 1010 vector genomes of AAV8 GFP. (C) Same section as B showing GFP epifluorescence. Arrows point to cells in pars compacta expressing GFP but not TH, showing that the AAV8 GFP vector at this dose resulted in loss of endogenous gene expression, not cell loss. Bar: 60 μm. A–C, same magnification.