Table 1.

Effect of N-aryl maleimide ring substitution on GST-Bfl-1 inhibition

Compound #	R1	Bfl-1 FPa IC50 (μM)	Bfl-1 TR-FRETa IC50 (μM)
1	3,4-dichloro-phenyl	0.6±0.1	0.8±0.1
8	3,5-dichloro-phenyl	2.4±0.4	1.9±0.2
9	2,4-dichloro-phenyl	2.6±0.2	1.4±0.1
10	2,3-dichloro-phenyl	8.7±1.7	2.6±0.1
11	2,6-dichloro-3-methyl-phenyl	23.9±3.9	11.1±2.3
12	2-chloro-phenyl	3.3±0.3	1.0±0.1
13	3-chloro-phenyl	2.1±0.2	1.2±0.1
14	3-methyl-phenyl	12.6±2.3	10.8±0.9
15	3-nitro-phenyl	6.8±1.4	3.9±0.4
16	3-Chloro-pyridin-4yl	29±3.9	35.6±3.9

^aData are the mean ± SEM.