Table 2.

SAR for analogs of “hit” 1 with varied Amines.

Compound #	R1	Bfl-1 FPa IC50 (μM)	Bfl-1 TR-FRETa IC50 (μM)
17		>50	>50
18		>50	>50
19		>50	>50
20		>50	>50
21		0.3±0.2	0.4±0.1
22		0.8±0.1	0.45±0.03
23		1.7±0.2	1.0±0.1
24		0.6±0.3	0.8±0.1
25		2.2±0.4	1.1±0.1
26		5.6±0.4	2.0±0.4
27		10.5±1.7	3.3±0.3
28		0.24±0.03	0.62±0.03
29		0.3±0.2	0.40±0.04
30		4.9±0.8	4.1±0.5
31		9.6±2.0	6.2±0.3
32		1.2±0.4	5.0±0.8
33		>10	8.3±2.1
34		>10	>10
35		>10	>10
36		2.4±0.2	1.3±0.1
37		4.1±0.4	2.1±0.2
38		0.25±0.05	0.69±0.03

^aData are the mean ± SEM.