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. Author manuscript; available in PMC: 2011 Jul 6.
Published in final edited form as: Biochemistry. 2010 Jul 6;49(26):5511–5523. doi: 10.1021/bi100157u

Figure 3. PD-linked mutants do not influence the subcellular localization or oligomerization state of LRRK2.

Figure 3

(A) PD-linked LRRK2 mutants and wild-type LRRK2 show similar distribution across the cytosol and membrane compartments when expressed in HEK293FT cells.

(B) Glycerol gradients of cytosol and membrane fractions from HEK293FT cells transfected with PD-linked LRRK2 mutants. The distribution of LMW and HMW LRRK2 in either cytosol or membrane fractions is not significantly changed by the introduction of PD-linked LRRK2 mutations (G2019S, R1441C, Y1699C) (Mean ± SEM, n = 3, Student’s t-test, all p > 0.05).

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