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Synthesis of N-dansyl daptomycin bisphosphonic acid (9). i) Dansyl-Lys (Boc)-NHS ester, Me2NCHO, r.t, overnight. ii) CF3CO2H: water: iPr3SiH (95:2.5:2.5), rt, 1h. iii) succinimidyl-TEG-maleimide, Me2NCHO, rt, overnight. iv) 2-(2-mercaptoethylamino) ethylidene-1, 1-bisphosphonic acid , 50% Me2NCHO/50% water.
