Table 3.

Local Volume Maxima of Volume Loss for the VBM Analysis Contrasts^a

Cluster Size	Voxel t Value	Voxel z Score	x, y, z Coordinates, mmb	Anatomical Localization
CBS Patients vs Healthy Controls
66 233	8.55	6.35	−32, 14, 70	Left midfrontal gyrus, BA 6
	7.81	5.99	−12, −44, 76	Left postcentral gyrus, BA 3
2202	7.12	5.64	8, 10, 16	Right caudate body
	6.46	5.27	4, −18, 16	Right thalamus
FTD-FV Patients vs Healthy Controls
31 020	6.64	5.2	58, 40, 22	Right midfrontal gyrus, BA 46
	6.39	5.07	34, 28, 58	Right midfrontal gyrus, BA 8
	6.39	5.06	4, 28, 64	Right midfrontal gyrus, BA 6
1391	6.4	5.07	8, 12, 14	Right caudate body
649	5.39	4.49	−4, 0, 14	Left caudate body
Local Gray Matter Volumes and UPSIT Scores in FTD-FV Patients
124	3.51	3.06	54, 36, 32	Right midfrontal gyrus, BA 46
Local Gray Matter Volumes and UPSIT Scores in CBS Patients
37	3.99	3.44	58, 28, −10	Right inferior frontal gyrus, BA 47
604	3.95	3.42	46, 0, 2	Right insula, BA 13
	3.88	3.37	52, −26, 16	Right insula, BA 40
	3.83	3.33	40, 16, −16	Right inferior frontal gyrus, BA 47
88	3.6	3.17	−54, 26, −8	Left inferior frontal gyrus, BA 47
	3.39	3.02	−58, 30, 10	Left inferior frontal gyrus, BA 46
31	3.34	2.98	52, 48, −4	Right midfrontal gyrus, BA 47

Abbreviations: BA, Brodmann area; CBS, corticobasal syndrome; FTD-FV, frontal variant of frontotemporal dementia; UPSIT, University of Pennsylvania Smell Identification Test; VBM, voxel-based morphometry.

^aFor all group comparisons and anatomical localizations, the uncorrected P values were .001. The statistical thresholds of the individual analysis are given in the “MRI Acquisition and Statistical Analysis” subsection of the “Methods” section.

^bAll the coordinates reported are according to the Montreal Neurological Institute standard space.